January Webinar

IES & EMBRN Joint Webinar:
Single Cell Dissection of Human Mast Cells, Basophils and Eosinophils

Wednesday, 22 January 2025

11:00 am - 12:30 pm US Eastern / 5:00 pm - 6:30 pm Central Europe

Register Here

Introducing an exciting collaboration: IES and EMBRN are launching a new joint membership opportunity for IES Regular Members and EMBRN Members! To celebrate, join us for a webinar on "Single Cell Dissection of Human Mast Cells, Basophils, and Eosinophils."  More information about this opportunity to come.

Our live webinars are completely free of charge, we just ask that you register in advance. Webinars are hosted on Zoom and audience members can ask questions using the Q&A feature. Real-time closed captioning is available for those with hearing impairments.

Program

11:00 am – 11:10 am: Introduction and Welcome
IES President: Marc Rothenberg - United States, EMBRN President: Gunnar Nilsson - Sweden
Moderators: TBC

11:10 am – 11:30 am: Mast Cells
Daniel Dwyer - United States

11:30 am – 11:35 am: Audience Q&A

11:35 am – 11:55 am: Basophils
Joakim Dahlin - Sweden

11:55 am – 12:00 pm: Audience Q&A

12:00 pm – 12:20 pm: Eosinophils
Netali Ben-Baruch Morgenstern - United States

12:20 pm – 12:25 pm: Audience Q&A

12:25 pm – 12:30 pm: Closing Remarks

Speakers & Moderators

Gerald Gleich

Daniel Dwyer, PhD

Dr. Dwyer received his BA in Biology from Amherst College and his PhD in Immunology from Harvard University, where he studied roles for B cells and innate granulocytes in initiating allergic inflammation. He continued his research on type 2 inflammation during his post-doctoral research with Dr. Nora Barrett at Brigham and Women’s Hospital, defining the transcriptional heterogeneity of murine connective tissue mast cells and using single-cell RNA sequencing to map the cellular contributors to human nasal polyposis and define mast cell heterogeneity within this disease.

Joakim Dahlin, PhD

Joakim Dahlin is Principal Investigator and Team Leader at Karolinska Institutet, Sweden. He received his PhD degree from Uppsala University in 2013, and he conducted postdoctoral research at Karolinska Institutet and the University of Cambridge, UK. In 2019, he became assistant professor at Karolinska Institutet and established his own group. He is now docent and principal researcher in experimental hematology. Joakim’s team develops and applies single-cell omics methods to chart human basophil and mast cell differentiation – to pinpoint how these cells contribute to maintaining health and how deregulation of these cells causes hematologic neoplasms.

Hirohito Kita

Netali Ben-Baruch Morgenstern, PhD

Dr.  Ben-Baruch Morgenstern joined the Rothenberg CURED Lab after completing her PhD at Tel Aviv University, where she studied the regulation of eosinophil hematopoiesis, chemotaxis, and activation by the inhibitory receptor Paired Immunoglobulin-like Receptor B (PIR-B). Her current research explores cellular composition, molecular characterization, and disease-promoting mechanisms in eosinophilic esophagitis (EoE) and eosinophilic gastritis (EoG). She aims to utilize single-cell RNA sequencing and protein analyses to create publicly available datasets and comprehensive analyses to identify new therapeutic targets for treating eosinophilic gastrointestinal diseases.

Roma Sehmi, PhD

Dr. Roma Sehmi is a Professor in the Department of Medicine at McMaster University with demonstrated expertise in investigating mechanisms of airway inflammation in asthma and COPD. She earned her PhD from the Royal Brompton National Heart and Lung Institute,Imperial College (London, UK), followed by post-doctoral fellowships at Cambridge University,UK, and McMaster University. As a translational scientist, Dr. Sehmi has pioneered methodologies to enumerate, phenotype and interrogate the functional role of rare cells in sputum. This has led to an improved understanding of the underlying mechanisms driving uncontrolled t2/t17 inflammatory responses in chronic inflammatory airways diseases. Her research currently focuses on the role of innate lymphoid cells in mediating disease exacerbations. Her investigations extend to novel alarmin and neuro-immune interactions driving innate lymphoid cell activation, plasticity and unraveling regulatory roles in pathobiological interactions within the airways. As a member of the Clinical Investigator Collaborative, she has been involved in evaluating investigational medications for asthma through Phase IIa-IIb proof-of-concept studies; shedding light on the mechanistic impacts of novel biologic therapies.

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